BOSTON — Chris Iannetta hit his second double of the game, a tie-breaking drive in the ninth inning off Red Sox closer Koji Uehara that sent the Los Angeles Angels over Boston 4-3 on Tuesday night.

Brennan Boesch had a ground-rule double with two outs off Uehara (5-3) for the Angels’ first hit since the fourth. Iannetta then lined a double off the left-field wall, just above the leap of Daniel Nava.

Joe Smith (5-1) got the win for the AL West leaders and Huston Street recorded his 34th save.

Angels right fielder Kole Calhoun made a sensational, leaping catch to rob Brock Holt of a three-run homer in the second. Calhoun made the grab at the low fence in front of his team’s bullpen to end the inning.

David Ortiz hit his 29th homer, a solo shot in the Boston first that increased his major league-leading total to 91 RBIs.

The Angels took a 3-1 lead in the third with four consecutive hits, starting with a double by Iannetta. The next three hits all drove in runs – a single by Calhoun, a triple by Mike Trout and a single by Albert Pujols.

Pujols originally was ruled out for the second out of the inning on Will Middlebrooks’ throw after the third baseman’s diving backhand stop. The call was overturned on replay, but Trout would have scored anyway on his headfirst slide into home.

Jered Weaver’s wildness led to Boston’s next two runs that tied it at 3 after six innings.

In the fifth, Dustin Pedroia singled, Ortiz walked and both advanced on a wild pitch. Pedroia scored on Mike Napoli’s groundout.

Xander Bogaerts began the sixth with a walk, took third on a single by Christian Vazquez and scored on a sacrifice fly by Holt.