Miami and New England are both 1-3 and both have perhaps their best quarterback on the sidelines.

Bourne has been out while recovering from a torn ACL suffered last October.

The QB is getting beat up, the offensive line is a mess and injuries are decimating the defense, but Coach Jerod Mayo is in it for the long haul.

Rhamondre Stevenson has fumbled four times in four games and could be replaced by Antonio Gibson as New England’s starter in the backfield.

New England quarterback Jacoby Brissett is sacked six times and has an interception returned for a touchdown.

New England is 1-2 under first-year head coach Jerod Mayo, while San Francisco is coming off back-to-back losses.

Left tackle Vederian Lowe (knee) and left guard Michael Jordan (ankle) were ruled out Friday and did not make the trip to face the 49ers.

Bosa is one of the top pass rushers in the NFL and New England’s offensive line is banged up.

Bentley suffered a torn pectoral muscle in Week 2 and is expected to miss the rest of the season.

Just 11 days after their season-opening upset of Cincinnati, the Patriots crashed hard against the Jets.