SAN FRANCISCO — Facebook CEO Mark Zuckerberg has a goal that’s even more ambitious than connecting the entire world to the Internet: He and his wife want to help eradicate all disease by the end of this century.

Zuckerberg and Priscilla Chan are committing $3 billion over the next 10 years to accelerate basic scientific research. That includes creating research tools – from software to hardware to yet-undiscovered techniques –they hope will ultimately lead to scientific breakthroughs, the way the microscope and DNA sequencing have in generations past.

The goal is to “cure, prevent or manage all disease” in the next 80 or so years, a timeframe the 30-something couple are unlikely to live to see. They acknowledge that this might sound crazy, but point to how far medicine and science have come in the last century – with vaccines, statins for heart disease, chemotherapy, and so on – following millennia with little progress.

At current rates of progress, Zuckerberg reckons, it will be possible to solve most of these problems “by the end of this century.” Zuckerberg and Chan have spent the past two years speaking to scientists and other experts to plan the endeavor. In an interview, Zuckerberg emphasized “that this isn’t something where we just read a book and decided we’re going to do.”

Through their philanthropic organization, the Chan Zuckerberg Initiative, the commitment includes $600 million to fund a new research center in San Francisco where scientific and medical researchers will work alongside engineers on projects spanning years or even decades. The goal is not to focus narrowly on specific ailments, such as bone cancer or Parkinson’s disease, but rather to do basic research. One example: a cell atlas that maps out all the different types of cells in the body, which could help researchers create various types of drugs.

Chan’s work as a pediatrician seems to be a big driver in the couple’s decision to take up this latest cause.

“I’ve been with families where we’ve hit the limit of what’s possible through medicine and science,” Chan said. “I’ve had to tell families devastating diagnoses of leukemia, or that we just weren’t able to resuscitate their child.”

Zuckerberg and Chan hope their commitment will inspire other far-reaching efforts and collaboration in science, medicine and engineering, so that basic research is no longer relegated to the margins. “We spend 50 times more on health care treating people who are sick than we spend on science research (to cure) diseases so that people don’t get sick in the first place,” Zuckerberg said.