Maine State Police arrested and charged four people after intercepting two shipments of drugs in unrelated investigations over the weekend, officials say.

Kenneth Ortega, 22, and Wayne Sudborough, 45, both of Waterville, were traveling on Friday along Interstate 395 in Brewer when a task force from the Maine Drug Enforcement Agency stopped them, according to a statement from state police spokesman Steve McCausland.

Agents had been surveying the vehicle after determining that it probably contained drugs, McCausland said. With help from Brewer and state police, the agents stopped the car and a police dog helped locate 35 grams of cocaine base, a few grams of cocaine and more than $3,500 in cash, according to McCausland.

Both men were charged with drug trafficking and taken to the Penobscot County Jail. They remain in custody, with their bail set at $50,000 each.

In an unrelated investigation, MDEA agents stopped two Machias-area women around 1:20 a.m. Saturday on Interstate 95 in Newport as they were traveling out of state to pick up drugs they planned to sell in Washington County, McCausland said.

Meredith Hinerman, 38, of Machiasport, and Holly Pellon, 51, of Machias, were both charged with aggravated trafficking after a state police drug detection helped find 75 grams of heroin and 100 oxycodone tablets in the vehicle.

Both women were taken to the Penobscot County Jail, where they remain in custody. Hinerman’s bail is set at $50,000 and Pellon’s bail is set at $75,000.