Cubs pitcher Shota Imanaga throws during the sixth inning against the Pittsburgh Pirates on Wednesday in Chicago. Charles Rex Arbogast/Associated Press

CHICAGO — Shota Imanaga and two Cubs relievers combined on a no-hitter, leading Chicago over the Pittsburgh Pirates 12-0 on Wednesday night.

Imanaga (12-3), a 31-year-old left-hander in his first season with the Cubs after pitching in Japan for eight seasons, struck out seven and walked two over seven innings. He threw 66 of 95 pitches for strikes.

He needed 25 pitches to get through the second inning. His season high is 103 pitches against St. Louis on June 15. Imanaga has not gotten an out in the eighth inning.

Imanaga agreed in January to a $53 million, four-year contract. Chicago paid a $9,825,000 posting fee to the Yokohama BayStars of Japan’s Central League.

Nate Pearson pitched a 1-2-3 eighth inning and Porter Hodge a perfect ninth in the Cubs’ 18th no-hitter, the first since Zach Davies, Ryan Tepera, Andrew Chafin and Craig Kimbrel combined to hold Los Angeles hitless at Dodger Stadium on June 24, 2021.

This was the fourth no-hitter this season after complete-game efforts by Houston’s Ronel Blanco against Toronto on April 1, San Diego’s Dylan Cease at Washington on July 25 and San Francisco’s Blake Snell at Cincinnati on April 2.

MARLINS 4, NATIONALS 3: Xavier Edwards hit an RBI single in the 10th inning and Miami beat visiting Washington.

Automatic runner Griffin Conine advanced to third on Nick Fortes’ groundout. Edwards followed with a soft line drive off Derek Law (7-3) that bounced into left field for Miami’s first win of the season against Washington after eight losses.

BRAVES 5, ROCKIES 2: Jarred Kelenic hit a three-run home run and Atlanta continued its mastery of visiting Colorado.

The Braves are now 16-3 against Colorado since the start of the 2022 season.

INTERLEAGUE

PHILLIES 4, BLUE JAYS 2: Kyle Schwarber matched a major league record with his 13th leadoff home run this season, Kody Clemens and JT Realmuto also went deep and visiting Philadelphia beat Toronto.

Cristopher Sánchez (10-9) struck out seven in seven innings for the NL East-leading Phillies (83-56), who have won four straight and 9 of 11.

A day after hitting three home runs, Schwarber went deep for the fourth time in seven at-bats and got his sixth hit in that span when he drove a 1-0 pitch from right-hander Bowden Francis into the second deck in right, matching Alfonso Soriano’s total.

The 416-foot drive was Schwarber’s 32nd home run of the season and he matched Brady Anderson for ninth with 44 leadoff homers. Hall of Famer Rickey Henderson leads with 81.

Schwarber finished 2 for 3. He singled in the second, struck out in the fifth and was replaced by a pinch runner after he walked in the eighth.

Phillies first baseman Bryce Harper left after he was hit on the left elbow by a 92 mph fastball in the first inning. Edmundo Sosa pinch hit for Harper to begin the third and took over at third base, with Clemens moving from third to first.

Sánchez didn’t walk a batter. He was charged with two runs and six hits, including five doubles.

Jeff Hoffman pitched the eighth and Carlos Estévez finished for his 24th save in 28 chances.

Daulton Varsho, Vladimir Guerrero Jr. and Alejandro Kirk gave Toronto a 2-1 lead by hitting consecutive doubles off Sánchez in the first but Clemens restored Philadelphia’s edge by homering in the second, his fourth this season.

Francis (8-4) allowed three runs and six hits in six innings, losing for the first time since Aug. 4.

Realmuto homered off right-hander Ryan Burr to start the ninth, his 12th.

REDS 12, ASTROS 5: Jonathan India led off Cincinnati’s nine-run first inning with a 436-foot homer and the Reds cruised to their second straight victory over visiting Houston.

The Reds went to work right away against Spencer Arrighetti (7-12), with India hitting his 11th career leadoff homer and the first since July 12.

Elly De La Cruz had a double and a single in the first, two RBI and his major league-leading 62nd stolen base. Tyler Stephenson and Amed Rosario each drove in two runs during the outburst.

AMERICAN LEAGUE

WHITE SOX 8, ORIOLES 1: Jonathan Cannon pitched into the sixth inning and visiting Chicago homered three times, snapping its 12-game losing streak.

Nicky Lopez, Andrew Vaughn and Dominic Fletcher went deep for the White Sox, who improved to 32-109 this season. They need to go 11-10 the rest of the way to avoid matching the post-1900 record of 120 losses by the 1962 New York Mets.

This was their third losing streak of at least 12 games this season — no team had ever done that since 1900 — but Lopez led off the game with a homer and the White Sox looked a lot sharper than they did while losing the first two games of this series by a combined 22-3.

RAYS 9, TWINS 4: Yandy Díaz hit a two-run homer in an eight-run fourth inning and Tampa Bay topped visiting Minnesota.

All eight runs were scored off Louie Varland (0-6), who was recalled from Triple-A St. Paul to follow opener Ronny Henríquez. Taylor Walls had a two-run single and José Caballero had an RBI single in the inning. The Rays also scored on a pair of fielder’s choice grounders with the infield in and an errant pickoff throw by Varland.

ROYALS 4, GUARDIANS 1: Tommy Pham hit his first home run for Kansas City, a tie-breaking, three-run drive in a four-run fourth inning, and the Royals stopped a season-high, seven-game losing streak with a win at home.

Seth Lugo (15-8) allowed one run and five hits in seven innings. He is one win behind Detroit’s Tarik Skubal and Atlanta’s Chris Sale, who are tied for the major league lead. Lugo is 11-1 with a 1.40 ERA in 15 starts with four days’ rest.

NOTES

RANGERS: Corey Seager was put on the 10-day injured list because of hip discomfort that could end the All-Star shortstop’s third season with Texas.

Seager didn’t play Tuesday night after being the designated hitter in the series opener.

Seager is hitting .278 with 30 home runs and 74 RBI in 123 games. He reached 30 homers for the third season in a row since signing his $325 million, 10-year contract with Texas as a free agent.

After surgery in January to repair a sports hernia, Seager played only the final three spring training games. He got off to a slow start with only two homers and eight RBI his first 29 regular-season games, but the 30-year-old has hit .296 with 27 homers and 66 RBI since May 3.

YANKEES: Clay Holmes won’t be the automatic choice as the closer for the Yankees in the short term after giving up a game-ending grand slam to the Texas Rangers for his major league-high 11th blown save this season.

Manager Aaron Boone said the club will consider several options, Holmes included, while continuing to support the two-time All-Star coming off a rough outing.

Rookie Wyatt Langford’s grand slam followed a single by Carson Kelly and consecutive walks to Josh Smith and Marcus Semien, giving the Rangers a 7-4 victory on Tuesday night.

“In the short term, we’ll kind of just get a little creative with it,” Boone said before the series finale against the Rangers. “I feel like he’s throwing the ball really well in a lot of ways. Last night it was certainly a little off and they got to him. But the reality is he’s really not that far off from being the dominant guy we know he can be.”

Langford fouled off a full-count slider to stay alive before hitting a hanging 85.8 mph slider 407 down the left-field line.

Holmes’ blown saves — which have come in 40 chances — are the most since Dave Righetti had 13 in 1987, tying the Yankees record set by Goose Gossage in 1983.

Boone stuck with Holmes after the right-hander’s previous blown save Aug. 18 against Detroit in Major League Baseball’s Little League Classic. Holmes had five scoreless outings with three saves before the loss to the Rangers.

The closer-by-committee decision from Boone came with the Yankees in a tight race with Baltimore for the best record in the American League and the AL East lead.

Right-hander Jake Cousins has a save and a 2.73 ERA with 45 strikeouts in 30 innings. Luke Weaver, another right-hander, is second to Holmes in appearances with 54 and has finished seven games. Left-hander Tim Hill is 3-0 with a 2.34 ERA in 27 relief outings but has just 13 strikeouts in 34 2/3 innings.

Rookie Luis Gil and Clarke Schmidt, both coming off the IL, could be developed into closing options.

RANGERS: Elvis Andrus, who made his big league debut as a 20-year-old shortstop for the Texas Rangers on Opening Day in 2009, is set to retire with his original club.

The 36-year-old Andrus will throw out the ceremonial first pitch before the Rangers’ home game Friday night against the Los Angeles Angels and Manager Ron Washington, who was Andrus’ skipper for his first five-plus seasons.

Andrus will be joined on the mound by Michael Young, who moved from shortstop to third base to make room for Andrus and is now a special assistant to Rangers GM Chris Young.

A two-time All-Star, Andrus was a steady presence up the middle when the Rangers went to back-to-back World Series in 2010-11. He was also part of AL West-winning teams in 2015-16.

As the club moved into a rebuilding mode almost a decade later, Andrus was traded to Oakland before the 2021 season. During his second season with the A’s, Andrus was sent to the Chicago White Sox.

Andrus spent 2023 in Chicago but remained unsigned this season.